Mass spectrometry is an analytical technique that measures the mass-to-charge ratio of ions. It is used in many different fields and is applied to pure samples as well as complex mixtures. The results are typically presented as a mass spectrum, a plot of intensity as a function of the mass-to-charge ratio. The atoms or molecules in the sample can be identified by correlating known masses to the identified masses or through a characteristic fragmentation pattern.

Mass spectrometry is a potential alternative to PCR which is the current reference method. It is rapid but still sensitive, accurate and high-performance detection for SARS-CoV-2 to diagnose infected people and to control the transmission of the virus. Alternative PCR and immunodiagnostic methodologies that would not require specific reagents are worth investigating not only to counter the COVID-19 pandemic but also to detect other emerging pathogenic threats.

A nanoLC-MS / MS acquisition method was developed to detect SARS-CoV-2 marker peptides in nasopharyngeal swabs spiked with different quantities of purified SARS-CoV-2 viral content using the tandem mass spectrometry detected the microbiota signal present in these samples is small and can be excluded when interpreting proteomic shotgun data obtained from a restricted peptidome landscape window.

Diagnostic Pathology: Open Access is collecting manuscripts all over the globe on COVID-19 to endorse the advancement of current knowledge pertaining to clinical studies and scientific investigations and foster discussion in all the relevant aspects of Pathology such as Immunopathology, Virtual Pathology, Tissue based Diagnosis, Immunohistochemistry, Diagnostic Pathology of Infectious Diseases.

We have also announced a Special Issue on “Therapeutic Applications in COVID-19” acknowledging the significance in the Global Scientific Community. The Special Issue is being edited by our honorable Executive Editorial Chair Person Dr. Maria Teresa Mascellino. The Submissions are Open!

Regards,

Matthew Richard
Diagnostic Pathology: Open Access
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