May NETs Contain Costimulatory Molecules?
May NETs Contain Costimulatory Molecules?
Journal of Immunobiology (Hilaris Publishing S.L) has announced almost 50% discount on article processing charge to commemorate its 10th Anniversary.
Journal of Immunobiology is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of Immunobiology, Immunology, Autoimmunity, Innate Immunity, Adaptive Immunity, immunization, Immunogenetics, Immune Disorders, Immunodeficiency, Immune inflammation, Immunoinformatics, Clinical Immunology, Allergy & Immunology, Clinical & Vaccine Immunology, Inflammatory Disorders, Autoimmune Disorders, Immunotherapy and Immunopathology of infectious, allergic and autoimmune disease etc.
It gives us great pleasure to announce the call for paper on the occasion of 10th Anniversary of the Journal at special and hefty discount of up to 50 % on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.
The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Short Communication which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.
Title: “May NETs Contain Costimulatory Molecules?”
Abstract: Since Neutrophil Extracellular Traps (NETs) were described in 2004 by Brikmann et al., they have been attributed to other functions in addition to catching and killing microorganisms. As it is known, NETs are formed by chromatin and granular proteins which after stimulation are released to the extracellular environment. Myeloperoxidase and neutrophil elastase are part of these structures and are actively involved in their release. The mechanism of NET formation implicates morphological changes of Polymorphonuclear (PMN) neutrophils: after activation, flattened and attached to the substratum, the nucleus of PMN lose their shape, the nuclear envelope and granules membrane disintegrate allowing the mixing of nuclear, cytoplasmic and granular components. Elastase migrates from the azurophilic granules to the nucleus and partially degradates histones, in this way promoting chromatin decondesation, and myeloperoxidase synergizes this action. Finally the plasmatic membrane ruptures and ejects the interior of the cell to the extracellular space forming NETs. NETs have not only been involved as defence mechanisms, but they have also been linked to tissue damage, thrombosis autoimmunity and cancer immunoediting. In patients with gout it has been described the formation of NETs with sterile inflammatory stimuli from crystals of monosodium urate (MSU).
To have a glance at the full length manuscript, you can visit us at our archive page and Currently, Journal’s Archive is holding not only normal issues but also focusing on special issues. The purpose of special issues is to publish the most exciting research with respect to the subjects of Immunology / Immunobiology and to provide a rapid turn-around time regarding reviewing and publishing, and to publicize the articles freely for research, teaching and reference purposes. Submit manuscript of your research articles or special issue articles online through manuscript submission or forwarded to the Editorial Office at immunobio@immunologyjournals.org
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David Williams
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Journal of Immunobiology