Regeneration of Pulp/Dentin-Like Tissue in Immature Necrotic Permanent Dog Teeth


Journal of oral hygiene and Health has announced almost 30 percent discount on article processing charge to commemorate its Anniversary. On behalf of the Journal of oral hygiene and Health the editor of Journal of oral hygiene and Health is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiatives that would encourage and reward our prospective audience which include clinicians, research scientists, decision-makers and a range of professionals in the Journal of oral hygiene and Health.


 Our aim was to evaluate the potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in the regeneration of canal pulp/dentin-like tissue and completion of root maturation of immature necrotic permanent dog teeth with apical periodontitis. A split-mouth design was used in 6 healthy male dogs. Four teeth were selected per dog (total, 24 teeth). The immature upper left second and third permanent incisors were designated as group A (experimental group), and contralateral teeth were designated as group B (control group). Periapical periodontitis was induced in both groups. After disinfection, group A received AD-MSCs and growth factors within a chitosan scaffold, whereas group B received growth factors within a chitosan scaffold. Periradicular healing, root-wall thickening and lengthening, and apical closure were blindly monitored radiographically for 4 months.


Painful and unpleasant dental problems such as pulp infection and periapical periodontitis can lead to difficulties in maintaining good oral hygiene, which further affects eating, drinking, taste, breathing, and well speech. These conditions can severely affect one’s quality life and well-being. Here, we demonstrated that implanting chitosan hydrogel scaffolds enriched with autologous AD-MSCs and growth factors might be useful in the regeneration of new pulp/dentin-like tissues in necrotic immature permanent teeth with apical periodontitis. AD-MSCs have the potential to survive well and generate new pulp/dentin-like tissues.

The Journal of oral hygiene and Health aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to vasculitis. The open access journal is published by OMICS International who hosts around 700 open access peer-reviewed journals as well as organizes more than 1000 International scientific Conferences.

The Journal is successfully running in the 8th Volume which covers a wide variety of Researchers of Oral Hygiene and Dental Health discipline are encouraged to publish innovative ideas in the international platform and peer reviewed journal of oral care and hygiene with good Impact factor. Oral hygiene, oral cancer, and oral surgery are some of the most evolving sectors of dental sciences, which still need more findings and communication.  

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